Learn More About Our Clinical Research

We are encouraged by the continually increasing body of evidence that demonstrates that the use of MyoPro results in clinically significant gains in a relatively short duration of in-person treatment. We look forward to expanding on these studies which may lead to innovations in treatment for patients who suffer from chronic upper extremity weakness,” said Harry Kovelman, M.D., Chief Medical Officer of Myomo. “This data supports why the payer community both in the U.S. and Germany continue to expand its reimbursement coverage for patients. We thank the clinicians and patients involved in these studies.

Summary Literature Review on Powered Orthoses for Arm Weakness

The following is a narrative summary of just some of the best contemporary studies on the efficacy of powered orthoses as applied in the rehabilitation and restoration of upper extremity function in patients with arm weakness following neurological insult. This summary is by a rehab clinician for rehab clinicians in talking to their colleagues in the health insurance field about why this technology is well proven and medically necessary.

ACRM Published Research

Giving Them a Hand: Wearing a Myoelectric Elbow-Wrist-Hand Orthosis Reduces Upper Extremity Impairment in Chronic Stroke

Abstract

Objective: To determine the immediate effect of a portable, myoelectric elbow-wrist-hand orthosis on paretic upper extremity (UE) impairment in chronic, stable, moderately impaired stroke survivors.

Design: Observational cohort study.

Setting: Outpatient rehabilitation clinic.

Participants: Participants exhibiting chronic, moderate, stable, poststroke, UE hemiparesis (NZ18).

Interventions: Subjects were administered a battery of measures testing UE impairment and function. They then donned a fabricated myoelectric elbow-wrist-hand orthosis and were again tested on the same battery of measures while wearing the device.

Main Outcome Measures: The primary outcome measure was the UE Section of the Fugl-Meyer Scale. Subjects were also administered a battery of functional tasks and the Box and Block (BB) test.

Results: Subjects exhibited significantly reduced UE impairment while wearing the myoelectric elbow-wrist-hand orthosis (FM: t17Z8.56, P<.0001) and increased quality in performing all functional tasks while wearing the myoelectric elbow-wrist-hand orthosis, with 3 subtasks showing significant increases (feeding [grasp]: zZ2.251, PZ.024; feeding [elbow]: zZ2.966, PZ.003; drinking [grasp]: zZ3.187, PZ.001). Additionally, subjects showed significant decreases in time taken to grasp a cup (zZ1.286, PZ.016) and increased gross manual dexterity while wearing a myoelectric elbow-wrist-hand orthosis (BB test: zZ3.42, P<.001).

Conclusions: Results suggest that UE impairment, as measured by the Fugl-Meyer Scale, is significantly reduced when donning a myoelectric elbow-wrist-hand orthosis, and these changes exceeded the Fugl-Meyer Scale’s clinically important difference threshold. Further, utilization of a myoelectric elbow-wrist-hand orthosis significantly increased gross manual dexterity and performance of certain functional tasks. Future work will integrate education sessions to increase subjects’ ability to perform multijoint functional movements and attain consistent functional changes.

References

1. Tyson S, Kent R. The effect of upper limb orthotics after stroke: A systematic review. Neuro Rehab. 2011; 28: 29-36.

2. Scott RN. Myoelectric control of prostheses and orthoses. Bulletin of Prosthetics Research, Univ. New Brunswick. Spring 1967. Online: http://www.rehab.research.va.gov/jour/67/4/1/93.pdf.

3. Peters HT, Page SJ, Persch A. Giving Them a Hand: Wearing a Myoelectric Elbow-Wrist-Hand Orthosis Reduces Upper Extremity Impairment in Chronic Stroke. Arch Phys Med Rehabil. 2017 Jan 24.

4. Ögce F, Özyalçin H. Case study: A myoelectrically controlled shoulder-elbow orthosis for unrecovered brachial plexus injury. Prosthet Orthot Int. 2000;24(3):252–255.

5. Waldner A, Tomelleri C, Hesse S. Transfer of scientific concepts to clinical practice: recent robot-assisted training studies. Funct Neurol. 2009 Oct-Dec;24(4):173-7.

6. Norouzi-Gheidari N, Archambault PS, Fung J. Effects of robot-assisted therapy on stroke rehabilitation in upper limbs: systematic review and meta-analysis of the literature. J Rehabil Res Dev. 2012;49(4):479-96.

7. Kim GJ, Rivera L, Stein J. Combined Clinic-Home Approach for Upper Limb Robotic Therapy After Stroke: A Pilot Study. Arch Phys Med Rehabil. 2015 Dec;96(12):2243-8.

8. Stein J, Narendran K, McBean J, Krebs K, Hughes R, Electromyography-Controlled
Exoskeletal Upper-Limb-Powered Orthosis for Exercise Training after Stroke. Am. J. Phys. Med. Rehabil. Vol. 86. No. 4. 2007.

9. Mayr A, Kofler M, Saltuari L. ARMOR: an electromechanical robot for upper limb training following stroke. A prospective randomised controlled pilot study. Handchir Mikrochir Plast Chir. 2008 Feb;40(1):66-73.

10. Takahashi CD, Der-Yeghiaian L, Le V, Motiwala RR, Cramer SC. Robot-based hand motor therapy after stroke. Brain. 2008 Feb;131(Pt 2):425-37.

11. Milot MH, Spencer SJ, Chan V, Allington JP, Klein J, Chou C, Bobrow JE, Cramer SC, Reinkensmeyer DJ. A crossover pilot study evaluating the functional outcomes of two different types of robotic movement training in chronic stroke survivors using the arm exoskeleton BONES. J Neuroeng Rehabil. 2013 Dec 19;10:112.

12. Lum PS, Burgar CG, Shor PC, Majmundar M, Van der Loos M. Robot-assisted movement training compared with conventional therapy techniques for the rehabilitation of upper-limb motor function after stroke. Arch Phys Med Rehabil. 2002 Jul;83(7):952-9.

13. Prange GB, Jannink MJ, Groothuis-Oudshoorn CG, Hermens HJ, Ijzerman MJ. Systematic review of the effect of robot-aided therapy on recovery of the hemiparetic arm after stroke. J Rehabil Res Dev. 2006;43(2):171–84.

14. Mehrholz J, Hadrich A, Platz T, Kugler J, Pohl M. Electromechanical and robot-assisted arm training for improving generic activities of daily living, arm function, and arm muscle strength after stroke. Cochrane Database Syst Rev. 2012;6:CD006876.

15. Klamroth-Marganska V, Blanco J, Campen K, Curt A, Dietz V, Ettlin T, Felder M, Fellinghauer B, Guidali M, Kollmar A, Luft A, Nef T, Schuster-Amft C, Stahel W, Riener R. Three-dimensional, task-specific robot therapy of the arm after stroke: a multicentre, parallel-group randomised trial. Lancet Neurol. 2014 Feb;13(2):159-66.

16. Wagner TH, Lo AC, Peduzzi P, Bravata DM, Huang GD, Krebs HI, et al. An economic analysis of robot-assisted therapy for long-term upper-limb impairment after stroke. Stroke. 2011;42(9):2630–2.

17. Maciejasz P, Eschweiler J, Gerlach-Hahn K, Jansen-Troy A, Leonhardt S. A survey on robotic devices for upper limb rehabilitation. J Neuroeng Rehabil. 2014 Jan 9;11:3.

18. Ren Y, Kang SH, Park HS, Wu YN, Zhang LQ. Developing a multi-joint upper limb exoskeleton robot for diagnosis, therapy, and outcome evaluation in neurorehabilitation. IEEE Trans Neural
Syst Rehabil Eng. 2013 May;21(3):490-9.

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